Annals of the New York Academy of Sciences
Thymosin beta 4: actin sequestration and beyond
2010
Goldstein AL et al.
All Products
Tissue / Repair Signaling Compound
TB-500
Thymosin Beta-4
Thymosin Beta-4 peptide fragment for tissue repair and regeneration research.
Vial Size
From
$35.00
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Research use only
Compound Information
Technical specifications
Molecular Profile
What is TB-500?
A synthetic fragment of the naturally occurring Thymosin Beta-4 protein, studied for actin regulation and cellular migration in vitro.
- Type
- Synthetic peptide fragment
- CAS Number
- 77591-33-4
- Molecular Weight
- 4963.4 g/mol
- Amino Acids
- 43
- Formula
- C₂₁₂H₃₅₀N₅₆O₇₈S
Storage Requirements
Stability Information
Protect from lightAvoid repeated freeze-thaw
Lyophilized (powder)
-20°C·up to 2 years
After opening
2-8°C·use within 30 days
Mechanism of Action
TB-500 is the active fragment of Thymosin β-4. It binds and sequesters G-actin, promoting actin-cytoskeleton remodeling, endothelial-cell migration, and angiogenesis — central to tissue-repair research.
Areas of Research
Soft-tissue and tendon repair
Cardiac and vascular regeneration models
Wound and corneal healing
Hair follicle stem-cell research
Purity
≥ 99% by independent third-party HPLC.
Half-Life
~2-3 hours systemic; localized tissue retention longer in research models.
Solubility
Freely soluble in aqueous diluents
Sources & References
Peer-reviewed research
Cardiovascular Research
Thymosin β4 in vascular development and repair
2012
Smart N et al.
About this compound
Overview
TB-500 is a synthetic peptide fragment related to the naturally occurring protein thymosin beta-4. It is a commonly studied research peptide and is supplied by PX-Labs as a lyophilized powder for laboratory research use only.
Background
TB-500 corresponds to a synthetic fragment of thymosin beta-4, a protein present in many cell types. As a synthetic, well-defined peptide, it is frequently used in laboratory research and is often studied together with BPC-157, including in the combination blend offered as Wolverine.
Specifications
- Compound
- TB-500 (synthetic thymosin beta-4 fragment)
- Form
- Lyophilized powder, sealed vial
- Purity
- ≥98%, verified by HPLC
- Testing
- Independent third-party analysis; COA available on request
- Available sizes
- 5mg, 10mg
- Presentation
- Lyophilized powder in a sealed research vial
Handling & Storage
In its lyophilized form, TB-500 is generally stored refrigerated and protected from light and moisture, with freezer storage common for longer-term holding. Standard laboratory handling practices apply.
Purity & Testing
Every batch is tested to a minimum of 98% purity by high-performance liquid chromatography, with analysis performed by an independent laboratory so results remain impartial. A Certificate of Analysis reporting identity, purity, and method is available on request.
Research Use Only
TB-500 is sold strictly for laboratory and scientific research. It is not intended for human or veterinary use, and PX-Labs is a research chemical supplier, not a compounding pharmacy. PX-Labs does not provide usage or application guidance.