The New England Journal of Medicine
Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1)
2021·PMID: 33567185
Wilding JPH et al.
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Metabolic Research Compound
Semaglutide
GLP-1 AgonistAcylated GLP-1 Analog
High-purity Semaglutide peptide for research.
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$45.00
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Research use only
Compound Information
Technical specifications
Molecular Profile
What is Semaglutide?
GLP-1 receptor agonist research compound studied for metabolic and weight management pathways.
- Type
- GLP-1 receptor agonist
- CAS Number
- 910463-68-2
- Molecular Weight
- 4113.6 g/mol
- Amino Acids
- 31 (modified)
Storage Requirements
Stability Information
Protect from lightAvoid repeated freeze-thaw
Lyophilized (powder)
-20°C·up to 2 years
After opening
2-8°C·use within 30 days
Mechanism of Action
Semaglutide selectively binds and activates the GLP-1 receptor, enhancing glucose-dependent insulin release, suppressing glucagon, slowing gastric emptying, and modulating hypothalamic appetite circuits.
Areas of Research
Glycemic regulation
Body-mass and appetite modulation (STEP program)
Cardiovascular outcome research (SELECT)
Neurodegenerative pathway research
Purity
≥ 99% by independent third-party HPLC.
Half-Life
~7 days
Solubility
Freely soluble in aqueous diluents
Sources & References
Peer-reviewed research
New England Journal of Medicine
Semaglutide and Cardiovascular Outcomes in Obesity (SELECT)
2023·PMID: 37952131
Lincoff AM et al.
About this compound
Overview
Semaglutide is a synthetic peptide studied as a GLP-1 receptor agonist. As a single-receptor incretin-class compound, it is a common reference point in comparative receptor research. PX-Labs supplies Semaglutide as a lyophilized powder for laboratory research use only.
Background
In the incretin class of research peptides, compounds are grouped by the receptors they target. Semaglutide acts at the GLP-1 receptor as a single agonist, which places it alongside dual agonists such as tirzepatide and triple agonists such as retatrutide in comparative receptor-activity studies. Its single-target profile makes it a frequent baseline in that line of research.
Specifications
- Compound
- Semaglutide (GLP-1 receptor agonist)
- Form
- Lyophilized powder, sealed vial
- Purity
- ≥98%, verified by HPLC
- Testing
- Independent third-party analysis; COA available on request
- Available sizes
- 5mg, 10mg
- Presentation
- Lyophilized powder in a sealed research vial
Handling & Storage
In its lyophilized form, Semaglutide is generally stored refrigerated and protected from light and moisture, with freezer storage common for longer-term holding. Standard laboratory handling practices apply.
Purity & Testing
Every batch is tested to a minimum of 98% purity by high-performance liquid chromatography, with analysis performed by an independent laboratory so results remain impartial. A Certificate of Analysis reporting identity, purity, and method is available on request.
Research Use Only
Semaglutide is sold strictly for laboratory and scientific research. It is not intended for human or veterinary use, and PX-Labs is a research chemical supplier, not a compounding pharmacy. PX-Labs does not provide usage or application guidance.