International Journal of Molecular Sciences
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Dermal / Cellular Research Compound
GHK-CU
Copper PeptideGly-His-Lys-Cu
Copper peptide complex for research.
Vial Size
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$35.00
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Research use only
Compound Information
Technical specifications
Molecular Profile
What is GHK-CU?
A naturally occurring copper-binding tripeptide (Gly-His-Lys-Cu) studied for collagen synthesis signaling and dermal fibroblast activity.
- Type
- Copper-peptide complex
- CAS Number
- 89030-95-5
- Molecular Weight
- 340.38 g/mol (free peptide)
- Molecular Weight (Cu)
- 401.91 g/mol (with copper)
- Amino Acids
- 3 (tripeptide)
- Sequence
- Gly-His-Lys
- Formula
- C₁₄H₂₄N₆O₄·Cu
Storage Requirements
Stability Information
Protect from lightAvoid repeated freeze-thawBlue color indicates copper binding
Lyophilized (powder)
-20°C·up to 2 years
After opening
2-8°C·use within 30 days
Mechanism of Action
GHK chelates Cu²⁺ to form a stable complex that modulates expression of genes involved in tissue repair, antioxidant defense, and collagen/elastin synthesis. It also signals through dermal fibroblasts and modulates MMP expression in connective-tissue research models.
Areas of Research
Collagen and elastin synthesis
Wound-healing and dermal repair models
Hair follicle size and growth research
Antioxidant and anti-inflammatory pathways
Skin remodeling after laser-resurfacing studies
Purity
≥ 99% by independent third-party HPLC.
Half-Life
Short systemic half-life; topical and SC research protocols vary.
Solubility
Freely soluble in water; copper-bound form has characteristic deep blue color.
Sources & References
Peer-reviewed research
BioMed Research International
GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration
Journal of Cosmetic Science
A 12-week, double-blind, placebo-controlled study of GHK-Cu facial cream
2005
Finkley et al.
Journal of Cosmetic Laser Therapy
Stimulation of collagen production by copper-peptide complex
2007
Appa Y et al.
Journal of Aging Science and Clinical Practice
Effects of GHK-Cu in nano-carriers on MMP expression and facial wrinkle parameters
2009
Gorouhi F, Maibach HI
Archives of Facial Plastic Surgery
Effects of Topical Copper Tripeptide Complex on CO2 Laser-Resurfaced Skin
2006·DOI: 10.1001/archfaci.8.4.252
Miller TR et al.
Various Sources
GHK-Cu effects on hair follicle growth and size
2020
Multiple researchers
Multiple Sources
GHK-Cu administration protocols
2018
Various clinical trials
Journal of Cosmetic Dermatology
Anti-inflammatory effects of GHK-Cu
2012
Campbell JD et al.
About this compound
Overview
GHK-Cu is a synthetic copper peptide — the tripeptide GHK (glycyl-L-histidyl-L-lysine) complexed with copper. It is supplied by PX-Labs as a lyophilized powder for laboratory research use only.
Background
GHK-Cu is a naturally occurring tripeptide-copper complex that is widely studied in peptide research. As a small, well-characterized copper-binding peptide, it is a common subject in laboratory study and is offered alongside the related copper peptide AHK-Cu. It also appears as a component in the GLOW and KLOW research blends.
Specifications
- Compound
- GHK-Cu (glycyl-histidyl-lysine copper tripeptide)
- Form
- Lyophilized powder, sealed vial
- Purity
- ≥98%, verified by HPLC
- Testing
- Independent third-party analysis; COA available on request
- Available sizes
- 50mg, 100mg
- Presentation
- Lyophilized powder in a sealed research vial
Handling & Storage
In its lyophilized form, GHK-Cu is generally stored refrigerated and protected from light and moisture, with freezer storage common for longer-term holding. Standard laboratory handling practices apply.
Purity & Testing
Every batch is tested to a minimum of 98% purity by high-performance liquid chromatography, with analysis performed by an independent laboratory so results remain impartial. A Certificate of Analysis reporting identity, purity, and method is available on request.
Research Use Only
GHK-Cu is sold strictly for laboratory and scientific research. It is not intended for human or veterinary use, and PX-Labs is a research chemical supplier, not a compounding pharmacy. PX-Labs does not provide usage or application guidance.